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Fakultät für Biologie, Chemie und Geowissenschaften

Lehrstuhl für Bioorganische Chemie Prof. Dr. Carlo Unverzagt

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Publikationen

2021

H. Hessefort, A. Gross, S. Seeleithner, M. Hessefort, T. Kirsch, L. Perkams, K. O. Bundgaard, K. Gottwald, D. Rau, C. G. Graf, E. Rozanski, S. Weidler, C. Unverzagt "Chemical and Enzymatic Synthesis of Sialylated Glycoforms of Human Erythropoietin", Angewandte Chemie, 2021, doi:10.1002/ange.202110013

A. Reif, K. Lam, S. Weidler, M. Lott, I. Boos, J. Lokau, C. Bretscher, M. Mönnich, L. Perkams, M. Schmälzlein, C. Graf, J.-P. Fischer, C. Lechner, K. Hallstein, S. Becker, M. Weyand, C. Steegborn, G. Schultheiss, S. Rose-John, C. Garbers, C. Unverzagt "Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance", Angewandte Chemie Int Ed, 2021, 60/24, 13380-13387, doi:10.1002/anie.202101496

K. Szymczak-Kulus, S. Weidler, A. Bereznicka, K. Mikolajczyk, R. Kaczmarek, B. Bednarz, T. Zhang, A. Urbaniak, M. Olczak, E. Y. Park, E. Majorczyk, K. Kapczynska, J. Lukasiewicz, M. Wuhrer, C. Unverzagt, M. Czerwinski "Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry", Journal of Biological Chemistry, 2021, 296, doi:10.1016/j.jbc.2021.100299

I. Alshanski, Y. Sukhran, E. Mervinetsky, C. Unverzagt, S. Yitzchaik, M. Hurevich "Electrochemical biosensing platform based on complex biantennary N-glycan for detecting enzymatic sialylation processes", Biosensors and Bioelectronics, 2021, 172, doi:10.1016/j.bios.2020.112762

2020

A. T. Pfretzschner, C. Unverzagt "Total synthesis of the chlorinated indigo-N-glycosides akashin A, B and C" Arkivoc, 2020, 4, 206–229, doi:10.24820/ark.5550190.p011.380

M. Weiss, D. Ott, T. Karagiannis, M. Weishaupt, M. Niemietz, S. Eller, M. Lott, M. Martínez‐Orts, Á. Canales, N. Razi, J. C. Paulson, C. Unverzagt "Efficient Chemoenzymatic Synthesis of N‐Glycans with a β1,4‐Galactosylated Bisecting GlcNAc Motif", Chembiochem, 2020, 21(22), 3212–3215,  doi:10.1002/cbic.202000268

M. Hessefort, H. Hessefort, S. Seeleithner, A. Gross, M. Lott, D. Rau, L. Kern, C. Unverzagt "Strategies for the highly efficient synthesis of erythropoietin N-glycopeptide hydrazides", Journal of Peptide Science, 2020, 27/1, doi:10.1002/psc.3283

M. Rothemund, A. Bär, F. Klatt, S. Weidler, L. Köhler, C. Unverzagt, C. D. Kuhn, R. Schobert "N-Metallocenoylsphingosines as targeted ceramidase inhibitors: Syntheses and antitumoral effects", Bioorganic Chemistry, 2020, 97, doi:10.1016/j.bioorg.2020.103703

2019

K. Streichert, C. Seitz, E. Hoffmann, I. Boos, W. Jelkmann, T. Brunner, C. Unverzagt, M. Rubini "Synthesis of Erythropoietins Site-Specifically Conjugated with Complex-Type N-Glycans" ChemBioChem, 2019, 20, 1914–1918.

M. M. Sauer, R. P. Jakob, T. Luber, F. Canonica, G. Navarra, B. Ernst, C. Unverzagt, T. Maier, R. Glockshuber "Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets" J. Am. Chem. Soc., 2019, 141, 936-944.

2018

M. I. Nielsen, J. Stegmayr, O. C. Grant, Z. Yang, U. J. Nilsson, I. Boos, M. C. Carlsson, R. J. Woods, C. Unverzagt, H. Leffler, H. H. Wandall "Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin-glycan specificities in a natural context" J. Biol. Chem., 2018, 293, 20249-20262.

T. Luber, M. Niemietz, T. Karagiannis, M. Mönnich, D. Ott, L. Perkams, J. Walcher, L. Berger, M. Pischl, M. Weishaupt, S. Eller, J. Hoffman, C. Unverzagt "A Single Route to Mammalian N-Glycans substituted with Core Fucose and Bisecting GlcNAc" Angew. Chem. Int. Ed., 2018, 57, 14543-14549.

C. Unverzagt, Y. Kajihara "Recent advances in the chemical synthesis of N-linked glycoproteins" Curr. Opin. Chem. Biol., 2018, 46, 130–137.

A. Cabanettes, L. Perkams, C. Spies, C. Unverzagt, A. Varrot "Recognition of complex core fucosylated N-glycans by a mini lectin" Angew. Chem. Int. Ed., 2018, 57, 10178-10181.

2017

A. Canales, I. Boos, L. Perkams, L. Karst, T. Luber, T. Karagiannis, G. Domínguez, F. J. Cañada, J. Pérez-Castells, D. Häussinger, C. Unverzagt, J. Jiménez-Barbero "Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins" Angew. Chem. Int. Ed., 2017, 56, 14987 –14991.

P. Sadana, M. Mönnich, C. Unverzagt, A. Scrima "Structure of the Y. pseudotuberculosis adhesin InvasinE" Protein Sci., 2017 Mar 31. doi: 10.1002/pro.3171

C. G. F. Graf, C. Schulz, M. Schmälzlein, C. Heinlein, M. Mönnich, L. Perkams, M. Püttner, I. Boos, M. Hessefort, J. N. Lombana Sanchez, M. Weyand, C. Steegborn, B. Breiden, K. Ross, G. Schwarzmann, K. Sandhoff, C. Unverzagt "Synthetic Glycoforms reveal Carbohydrate-Dependent Bioactivity of Human Saposin D" Angew. Chem. Int. Ed., 2017, 56, 5252-5257.

A. Gimeno, N. C. Reichardt, F. J. Cañada, L. Perkams, C. Unverzagt, J. Jiménez-Barbero, A. Ardá "NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features" ACS Chem Biol., 2017 Mar 3. doi: 10.1021/acschembio.6b01116

S. Riethmueller, P. Somasundaram, J. C. Ehlers, C.-W. Hung, C. M. Flynn, J. Lokau, M. Agthe, S. Düsterhöft, Y. Zhu, J. Grötzinger, I. Lorenzen, T. Koudelka, K. Yamamoto, U. Pickhinke, R. Wichert, C. Becker-Pauly, M. Rädisch, A. Albrecht, M. Hessefort, D. Stahnke, C. Unverzagt, S. Rose-John, A. Tholey, C. Garbers "Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation" PLOS Biology, 2017, 15, e2000080.

2016

M. Mönnich, S. Eller, T. Karagiannis, L. Perkams, T. Luber, D. Ott, M. Niemietz, J. Hoffman, J. Walcher, L. Berger, M. Pischl, M. Weishaupt, C. Wirkner, R. G. Lichtenstein, C. Unverzagt "Highly Efficient Synthesis of Multiantennary Bisected N-glycans Based on Imidates" Angew. Chem., 2016, 128, 10643 –10648, Angew. Chem. Int. Ed., 2016, 55, 10487–10492.

2015

A. Audfray, M. Beldjoudi, A. Breiman, A. Hurbin, I. Boos, C. Unverzagt, M. Bouras, S. Lantuejoul, J.-L. Coll, A. Varrot, J. Le Pendu, B. Busser, A. Imberty "A Recombinant Fungal Lectin for Labeling Truncated Glycans on Human Cancer Cells" PLOS One, 2015, 10, e0128190.

A. S. F. do Nascimento, S. Serna, A. Beloqui, A. Arda, A. H. Sampaio, J. Walcher, D. Ott, C. Unverzagt, N.-C. Reichardt, J. Jimenez-Barbero, K. S. Nascimento, A. Imberty, B. S. Cavada and A. Varrot "Algal lectin binding to core (α1–6) fucosylated N-glycans: Structural basis for specificity and production of recombinant protein" Glycobiology, 2015, 25, 607–616.

2014

C. Pöhner, V. Ullmann, R. Hilpert, E. Samain, C. Unverzagt "Chemoselective coupling of sugar oximes and a-ketoacids to glycosyl amides and N-glycopeptides" Tetrahedron Lett., 2014, 55, 2197-2200. 

A. Reif, S. Siebenhaar, A. Tröster, M. Schmälzlein, C. Lechner, P. Velisetty, K. Gottwald, C. Pöhner, I. Boos, V. Schubert, S. Rose-John, C. Unverzagt "Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6" Angew. Chem., 2014, 126, 12321 –12327, Angew. Chem. Int. Ed., 2014, 53, 12125 –12131.

2013

A. Canales, A. Mallagaray, J. Pérez-Castells, I. Boos, C. Unverzagt, S. André, H.-J. Gabius, F. J. Cañada, J. Jiménez-Barbero "Breaking Pseudo-Symmetry in Multiantennary Complex N-Glycans Using Lanthanide-Binding Tags and NMR Pseudo-Contact Shifts" Angew. Chem. Int. Ed., 2013, 52, 13789-13793.

C. Unverzagt, Y. Kajihara "Chemical assembly of N-glycoproteins: a refined toolbox to address a ubiquitous posttranslational modification" Chem. Soc. Rev., 2013, 42, 4408-4420.

A. Ardá, P. Blasco, D. Varón Silva, V. Schubert, S. André, M. Bruix, F. J. Cañada, H.-J. Gabius, C. Unverzagt, J. Jiménez-Barbero "Molecular Recognition of Complex-Type Biantennary N‑Glycans by Protein Receptors: a Three-Dimensional View on Epitope Selection by NMR" J. Am. Chem. Soc., 2013, 135, 2667-2675.

2012

V. Ullmann, M. Rädisch, I. Boos, J. Freund, C. Pöhner, S. Schwarzinger, C. Unverzagt "Convergent Solid Phase Synthesis of N-Glycopeptides supported by Pseudoprolines at Consensus Ser/Thr Residues" Angew. Chem. Int. Ed., 2012, 51, 11566-11570.

D. Ott, J. Seifert, I. Prahl, M. Niemietz, J. Hoffman, J. Guder, M. Mönnich, C. Unverzagt "Modular Synthesis of Core Fucosylated N-Glycans" Eur. J. Org. Chem., 2012, 5054-5068.

R. G. Benevides, G. Ganne, R. da Conceição Simões, V. Schubert, M. Niemietz, C. Unverzagt, V. Chazalet, C. Breton, A. Varrot, B. Sousa Cavada, A. Imberty "A lectin from Platypodium elegans with unusual specificity and affinity for asymmetric complex N-glycans" J. Biol. Chem., 2012, 287, 26352-26364.

N. Bovin, P. Obukhova, N. Shilova, E. Rapoport, I. Popova, M. Navakouski, C. Unverzagt, M. Vuskovic, M. Huflejt "Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies?" Biochim. Biophys. Acta, 2012, 1820, 1373-82.

2011

M. Niemietz, L. Perkams, J. Hoffman, S. Eller, C. Unverzagt "Selective Oxidative Debenzylation of Mono- and Oligosaccharides in the Presence of Azides" Chem. Commun., 2011, 47, 10485–10487.

C. Heinlein, D. Varón Silva, A. Tröster, J. Schmidt, A. Gross, C. Unverzagt "Fragment condensation of C-terminal pseudoproline peptides without racemization on the solid phase" Angew. Chem., 2011, 123, 6530–6534, Angew. Chem. Int. Ed., 2011, 50, 6406–6410.

2010

M. Veelders, Stefan Brückner, Dimitri Ott, Carlo Unverzagt, H.-U. Mösch, and L.-O. Essen "Structural basis of flocculin-mediated social behavior in yeast" Proc. Natl. Acad. Sci. USA, 2010, 107, 22511-22516.

S. Mezzato, C. Unverzagt "Synthesis of an Fmoc-Asn-heptasaccharide building block and its application to chemoenzymatic glycopeptide synthesis" Carbohydr. Res., 2010, 345, 1306-1315.

J. J. Hernández-Gay, A. Ardá, S. Eller, S. Mezzato, B. R. Leeflang, C. Unverzagt, F. J. Cañada, J. Jiménez-Barbero "Insights into the Dynamics and Molecular Recognition Features of Glycopeptides by Protein Receptors. The three-dimensional Solution Structure of Hevein bound to the Trisaccharide core of N-Glycoproteins" Chem. Eur. J., 2010, 16, 10715-10726.

S. Eller, C. Raps, M. Niemietz, C. Unverzagt "Convenient introduction of a bisecting GlcNAc residue into multiantennary N-glycans as the ultimate residue" Tetrahedron Lett., 2010, 51, 2648-2651.

2009

C. Unverzagt, G. Gundel, S. Eller, R. Schuberth, J. Seifert, H. Weiss, M. Niemietz, M. Pischl, C. Raps "Synthesis of Multiantennary Complex Type N-Glycans by Use of Modular Building Blocks" Chem. Eur. J., 2009, 15, 12292-12302.

S. André, T. Kozár, S. Kojima, C. Unverzagt and H.-J. Gabius "From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans" Biol. Chem., 2009, 390, 557–565.

C. Piontek, D. Varón Silva, C. Heinlein, C. Pöhner, S. Mezzato, P. Ring, A. Martin, F. X. Schmid and C. Unverzagt "Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C Part 2" Angew. Chem. Int. Ed., 2009, 121, 1974-1978. DOI: 10.1002/anie.200804735

C. Piontek, P. Ring, O. Harjes, C. Heinlein, S. Mezzato, N. Lombana, C. Pöhner, M. Püttner, D. Varón Silva, A. Martin, F. X. Schmid, C. Unverzagt "Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C Part 1" Angew. Chem. Int. Ed., 2009, 48, 1936-1940. DOI: 10.1002/anie.200804734

S. Ryczek, K. Dettner, C. Unverzagt "Synthesis of buprestins D, E, F, G and H- structural confirmation and biological testing of acyl glucoses from jewel beetles (Coleoptera: Buprestidae)" Bioorg. Med. Chem., 2009, 17, 1187-1192.

2008

J.-P. Gourdine, G. Cioci, L. Miguet, C. Unverzagt, D. Varón Silva, A. Varrot, C. Gautier, E. J. Smith-Ravin, A. Imberty "High Affinity Interaction between a Bivalve C-type Lectin and a Biantennary Complex-type N-Glycan Revealed by Crystallography and Microcalorimetry" J. Biol. Chem., 2008, 283, 30112-30120.

C. Unverzagt, S. Eller, S. Mezzato, R. Schuberth "A Double Regio and Steroselective Glycosylation Strategy for the Synthesis of N-Glycans" Chem. Eur. J., 2008, 1304-1311.

2007

S. Andre, T. Kozar, R. Schuberth, C. Unverzagt, S. Kojima, H.-J. Gabius "Substitutions in the N-Glycan Core as Regulators of Biorecognition: The Case of Core-Fucose and Bisecting GlcNAc Moieties" Biochemistry, 2007, 46, 6984-6995.

S. Eller, R. Schuberth, G. Gundel, J. Seifert, C. Unverzagt "Synthese von pentaantennären N-Glycanen mit Bisecting-GlcNAc und Core-Fucose" Angew. Chem., 2007, 119, 4251-4253, Angew. Chem. Int. Ed., 2007, 46, 4173-4175.

2006

S. Schramm, K. Dettner, C. Unverzagt "Chemical and enzymatic synthesis of buprestin A and B-bitter acylglucosides from Australian jewel beetles (Coleoptera: Buprestidae)" Tetrahedron Lett., 200647, 7741-7743.

S. Andre, S. Kojima, G. Gundel, R. Russwurm, X. Schratt, C. Unverzagt, H.-J. Gabius "Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand properties" Biochim. Biophys. Acta, 2006, 1760, 768-82.

2005

E. I. Park, Y. Mi, C. Unverzagt, H.-J. Gabius, J. U. Baenziger "The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acidalpha2,6GalNAc" Proc. Natl. Acad. Sci. USA, 2005, 102, 17125-9.

S. André, S. Kojima, I. Prahl, M. Lensch, C. Unverzagt, H.-J. Gabius "Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycan" FEBS J., 2005, 272, 1986-98.

R. Schuberth, C. Unverzagt "Synthesis of a N-Glycan nonasaccharide of the bisecting type with additional core-fucose" Tetrahedron Lett., 2005, 46, 4201-4204.

E. Bedini, C. De Castro, G. Erbs, L. Mangoni, J. M. Dow, M. A. Newman, M. Parrilli, C. Unverzagt "Structure-Dependent Modulation of a Pathogen Response in Plants by Synthetic O-Antigen Polysaccharides" J. Am. Chem. Soc., 2005, 127, 2414-2416.

S. Mezzato, M. Schaffrath, C. Unverzagt "An Orthogonal Double-Linker Resin Facilitates the Efficient Solid-Phase Synthesis of Complex-Type N-Glycopeptide Thioesters Suitable for Native Chemical Ligation" Angew. Chem., 2005, 117, 1677-1681, Angew. Chem. Int. Ed., 2005, 44, 1650-1654.

X. Schratt, C. Unverzagt "Synthesis of an N-glycan decasaccharide of the hybrid type" Tetrahedron Lett., 2005, 46, 691-694.

2004

C. Lorenz, P. Hadwiger, M. John, H. P. Vornlocher, C. Unverzagt "Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells" Bioorg. Med. Chem. Lett., 2004, 14, 4975-4977.

S. Reicheneder, C. Unverzagt "Synthesis of Dimeric Terpenoyl Glycoside side Chains from Cytotoxic Saponins" Angew. Chem., 2004, 116, 4459-4457, Angew. Chem. Int. Ed., 2004, 43, 4354-4357.

U. Jeschke, G. Gundel, H. Müller, D.-U. Richter, A. Streu, V. Briese, I. Mylonas, K. Friese, C. Unverzagt "N-glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro" J. Perinat. Med., 2004, 32, 248-253.

S. André, C. Unverzagt, S. Kojima, M. Frank, J. Seifert, C. Fink, K. Kayser, C.-W. von der Lieth, H.-J. Gabius "Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo" Eur. J. Biochem., 2004, 271, 117-134.

E. Bedini, G. Barone, C. Unverzagt, M. Parrilli "Synthesis of the pentasaccharide repeating unit of the major O-antigen component from Pseudomonas syringae pv. ribicola NVPPB 1010" Carbohydr. Res., 2004, 32, 248-253.

M. Schnabel, B. Römpp, D. Ruckdeschel, C. Unverzagt "Synthesis of tryptophan N-glucoside" Tetrahedron Lett., 2004, 45, 295-297.

2003

H. Weiss, C. Unverzagt "Highly branched Oligosaccharides: a General Strategy for the Synthesis of multiantennary N-Glycans carrying the Bisecting Motif" Angew. Chem., 2003, 115, 4389-4392, Angew. Chem. Int. Ed., 2003, 42, 4261-4263.

G. Voss, M. Gradzielski, J. Heinze, H. Reinke, C. Unverzagt "Highly soluble and Green Indigo Dyes: 4,4´,7,7`-Tetraalkoxy-5,5`-diaminoindigotins" Helv. Chim. Acta, 2003, 86, 1982-2004.

C. Unverzagt "Synthesis of a Core Trisaccharide as a Versatile Building Block for N-Glycans and Glycoconjugates" Chem. Eur. J., 2003, 9, 1369-1376.

2002

E. Bedini, M. Parrilli, C. Unverzagt "Oligomerization of a rhamnanic trisaccharide repeating unit of O-chain polysaccharides from phytopathogenic bacteria" Tetrahedron Lett., 2002, 43, 8879-8882.

I. Prahl, C. Unverzagt "Enzymatic elongation of the LEC14 Antigen Generates a novel ß-1,2 Arm on N-Glycans" Angew. Chem., 2002, 114, 4434-4437, Angew. Chem. Int. Ed. Engl., 2002, 114, 4259-4262.

D. Varón, E. Lioy, M. E. Patarroyo, X. Schratt, C. Unverzagt "Synthesis of Mannosyl and Oligomannosyl Threonine Building Blocks Found on the Mycobacterium tuberculosis 45 kDa MPT 32 Glycoprotein" Aust. J. Chem., 2002, 55, 161.

C. Unverzagt, J. Seifert, S. André, S. Kojima, C. Fink, G. Srikrishna, H. Freeze, K. Kayser, H.-J. Gabius "Structure-Activity Profiles of Complex Biantennary Glycans with Core Fucosylation and with/without Additional a2,3/a2,6 Sialylation: Synthesis of Neoglycoproteins and Their Performance in Lectin Assays, Cell Binding and Organ Uptake" J. Med. Chem., 2002, 45, 478-491.

2001

J. Peter, C. Unverzagt, T. N. Krogh, O. Vorm, W. Hoesel "Identification of pro forms of free prostate specific antigen (F-PSA) from serum of prostate cancer patients by immunosorption and mass spectrometry" Cancer Res., 2001, 61, 957-962.

2000

I. Prahl, C. Unverzagt "Synthesis of a LEC14 nonasaccharide, a core-fucosylated, biantennary N-glycan with a novel GlcNAc residue in the core region" Tetrahedron Lett., 2000, 41, 10189-10193.

G. Kuznik, C. Unverzagt, B. Hörsch, G. Kretzschmar "Chemical and enzymatic Synthesis of Modified Sialyl Lewis X Tetrasaccharides with High Affinity for E- and P-Selectin" J. Prakt. Chem., 2000, 342, 745-752.

C. Unverzagt, J. Seifert "Chemoenzymatic synthesis of deca and dodecasaccharide N-glycans of the 'bisecting' type" Tetrahedron Lett., 2000, 41, 4549-4553.

J. Peter, C. Unverzagt, W. Hoesel "Analysis of Prostate-Specific Antigen (PSA) after Chemical Release from the Complex with a1-Antichymotrypsin (PSA-ACT)" Clin. Chem., 2000, 46, 474-482.

H.-J. Gabius, N. V. Bovin, U. Brinck, S. Gabius, C. Unverzagt, K. Kayser "Carrier-immobilized Carbohydrate Ligands: Design of the Lectin-Detecting Tools and their Clinical Applications with Focus on Histopathology" in: Lectins and Pathology (Eds: M. Caron and A.-P. Seve) Harwood Academic Publishers, 2000, 01.05.1934.

1999

J. Peter, C. Unverzagt, H. Lenz, W. Hoesel "Purification of Prostate-Specific Antigen from Human Serum by indirect Immunosorption and Elution with a Hapten" Analytical Biochem., 1999, 273, 98-104.

1998

C. Unverzagt "Chemical and Enzymatic Synthesis of a Sialylated Biantennary N-Glycan linked to Asparagine" Carbohydr. Res., 1998, 305, 423-431.

H.-J. Gabius, C. Unverzagt, K. Kayser "Beyond Plant Lectin Histochemistry: Preparation and Application of Markers to visualize the Cellular Capacity for Protein-Carbohydrate Recognition" Biotech. Histochem., 1998, 73, 263-277.

J. Peter, C. Unverzagt, W.-D. Engel, D. Renauer, C. Seidel, W. Hösel "Identification of Carbohydrate Deficient Transferrin Forms by MALDI-TOF and Lectin ELISA" Biochem. Biophys. Acta, 1998, 1380, 93-101.

C. Unverzagt "Trends: Organische Chemie-Kohlenhydratchemie 1997" Nachr. Chem. Tech. Lab., 1998, 46, 163-166.

1997

S. André, C. Unverzagt, S. Kojima, X. Dong, C. Fink, K. Kayser, H.-J. Gabius "Neoglycoproteins with the Synthetic Complex Biantennary Nonasaccharide or its a2,3/a2,6-Sialylated Derivatives: Their Preparation, Assessment of their Ligand Properties for Purified Lectins, for Tumor Cells in vitro and in Tissue Sections and their Biodistribution in Tumor-Bearing Mice" Bioconjugate Chem., 1997, 8, 845-855.

J. Seifert, C. Unverzagt "Synthesis of three Biantennary N-Glycans containing the a-1,6-Core-Fucosyl Motif" Tetrahedron Lett., 1997, 38, 7857-7860.

C. Unverzagt "A Modular System for the Synthesis of Complex N-Glycans" Angew. Chem., 1997, 109, 2078-2081, Angew. Chem. Int. Ed. Engl., 1997, 36, 1989-1992.

C. Unverzagt "Building Blocks for Glycoproteins: Synthesis of the Ribonuclease B Fragment 21-25 containing  an Undecasaccharide N-Glycan" Tetrahedron Lett., 1997, 38, 5627-5630.

G. Kuznik, B. Hörsch, G. Kretzschmar, C. Unverzagt "Chemical and enzymatic Synthesis of high-Affinity Ligands for E- and P-Selectin" Bioorg. Med. Chem. Lett., 1997, 5, 577-580.

1996

C. Unverzagt "Chemoenzymatic Synthesis of a Sialylated Undecasaccharide-Asparagine" Angew. Chem., 1996, 108, 2507-2510, Angew. Chem. Intl. Ed. Engl., 1996, 35, 25350-25353.

C. Unverzagt "Chemoenzymatic Synthesis of the fully glycosylated Ribonuclease Fragment 57-61" Y. Shimonishi (Ed.), Proceedings of the 6th Akabori Conference, German-Japanese Symposium on Peptide Chemistry, 1996, 36-39.

J. Seifert, C. Unverzagt "Synthesis of a Core-Fucosylated, Branched Octasaccharide as a Precursor for Glycopeptides of Complex N-Glycans" Tetrahedron Lett., 1996, 37, 6537-6530.

1995

C. Unverzagt "Transaminations and miscellaneous reactions" in: Enzyme Catalysis in Organic Synthesis (Eds: K. Drauz and H. Waldmann), VCH, Weinheim, 1995, 470-480.

C. Unverzagt "Chemistry of b-lactams" in: Enzyme Catalysis in Organic Synthesis (Eds: K. Drauz and H. Waldmann), VCH, Weinheim, 1995, 458-470.

1994

C. Unverzagt, H. Kunz "Synthesis of Glycopeptides and Neoglycoproteins containing the fucosylated linkage region of N-Glycoproteins" Bioorg. Med. Chem., 1994, 2, 1189-1201.

C. Unverzagt "Synthesis of a Biantennary Heptasaccharide by Regioselective Glycosylations" Angew. Chem., 1994, 106, 1170-1173, Angew. Chem. Int. Ed. Engl., 1994, 33, 1102-1104.

C. Unverzagt, S. Kelm, J. C. Paulson "Chemical and enzymatic Synthesis of multivalent Sialoglycopeptides" Carbohydr. Res., 1994, 251, 285-301.

H. Kunz, K. von dem Bruch, C. Unverzagt, W. Kosch "Synthesis of glycopeptides: a challenge for chemical selectivity" R. S. Hodges, J. A. Smith (Eds.) Pept. Chem., Struct. Biol., 1994, Proceedings of the 13th American Peptide Symposium, Escom Leiden, 321-323.

1993

H. Kunz, C. Unverzagt, B. Dombo, W. Kosch, H. Waldmann "Synthesis of glycopeptide partial structures of virus coat glycoproteins" Chem. Pept. Proteins, 1993, 5/6(Pt. A), 81-89.

C. Unverzagt "Got the Flu? Try a Designer Agent Derived from a Sugar" Angew. Chem., 1993, 105, 1762-1764, Angew. Chem. Int. Ed. Engl., 1993, 32, 1691-1693.

1992

A. Geyer, D. F. Mierke, C. Unverzagt, H. Kessler "Synthesis of cyclic  thiohexapeptides" Peptides, 1992, C. H. Schneider, A. N. Eberle (Eds.), Proceedings of the Twenty-Second European Peptide Symposium, Escom Leiden, 599-600.

C. Unverzagt, A. Geyer, H. Kessler "Chain Elongation of Thiodipeptides with Proteases" Angew. Chem., 1992, 104, 1231-1233, Angew. Chem. Int. Ed. Engl., 1992, 31, 1229-1230.

H. Kunz, W. Kosch, J. März, M. Ciommer, W. Guenther, C. Unverzagt "Synthesis of glycopeptides in solution and on solid phases" R. Epton (Ed.), Innovation Perspect. Solid Phase Synth. Collect. Pap., Int. Symp., 2nd Meeting, 1991, Editor(s):, Roger. Intercept: Andover, 1992, 171-178.

C. Unverzagt, H. Kunz "Stereoselective Synthesis of Glycosides and anomeric Azides of Glucosamine" J. Prakt. Chem., 1992, 334, 570-578.

H. Kunz, C. Unverzagt "Synthesis of a-Fucosyl Glycosides and Disaccharides using 4-Methoxybenzyl (Mpm) protected Fucosyl Donors" J. Prakt. Chem., 1992, 334, 579-583.

1990

C. Unverzagt, H. Kunz, J. C. Paulson "High Efficiency Synthesis of  Sialyloligosaccharides and Sialoglycopeptides" J. Am. Chem. Soc., 1990, 112, 39308-9309.

1989

H. Kunz, C. Unverzagt "Synthesis of Glycopeptides related to the Core Regions of  N-Glycoproteins" E. Wünsch (Ed.), Proceedings of the 3rd Akabori Conference, German-Japanese Symposium on Peptide Chemistry, 1989, 54-58.

1988

H. Kunz, C. Unverzagt "Protecting-Group-Dependent Stability of Intersaccharide Bonds-Synthesis of a Fucosyl-Chitobiose Glycopeptide" Angew. Chem., 1988, 100, 1763-1765, Angew. Chem. Int. Ed. Engl., 1988, 27, 1697.

H. Kunz, S. Friedrich-Bochnitschek, S. Birnbach, C. Unverzagt "Synthesis of Glycopeptides with Tn- and T-Antigen Structure using New Protecting Techniques" Peptide Chemistry, 1987, T. Shiba & S. Sakakibara (Ed.), Protein Research Foundation, Osaka, 1988, 323-326.

Review: C. Unverzagt, H. Kunz "Synthesis of Glycopeptide Partial Structures of Glycoproteins - a Challenge for selective protecting Group Techniques" GIT Fachzeitschrift für das Laboratorium, 1988, 6, 599-604.

1987

H. Kunz, H. Waldmann, C. Unverzagt "Synthesis of Glycopeptides using the Allyl Ester and the Allyloxycarbonyl Group as protecting Functions" Peptides, 1986, Editor: D. Theodoropoulos, Walter de Gruyter & Co. Berlin, 1987, 615-618.

H. Kunz, H. Waldmann, C. Unverzagt "Allylester as temporary protecting group for the b-carboxy function of aspartic acid" Int J. Pept. Prot. Res., 1987, 26, 493.

1984

H. Kunz, C. Unverzagt "The Allyloxycarbonyl (Aloc) Moiety-Conversion of an Unsuitable into a Valuable Protecting Group for Peptide Synthesis" Angew. Chem., 1984, 96, 426-427, Angew. Chem. Int. Ed. Engl., 1984, 23, 436-437.


Verantwortlich für die Redaktion: Volker Schubert

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